The failure of immune surveillance may be associated with polyomavirus BK reactivation, potentially leading to the development of nephropathy in kidney transplantation. BK-specific cellular immune response may be used to modulate immunosuppressive therapy, but few studies have investigated the topic. Herein, we serially evaluated BK-specific response in 149 kidney transplant recipients and found that only 14/149 (9.4%) were responders. Episodes of viral reactivation (viremia and/or viruria) occurred only in non-responder patients. The frequency of BK-specific immune response appears to be lower than that for other persistently infecting viruses such as cytomegalovirus.

Evaluation of polyomavirus BK cellular immune response by an ELISpot assay and relation to viral replication in kidney transplant recipients.

Costa C.;SINESI, Franca;SIDOTI, Francesca;CAVALLO, Rossana
2014

Abstract

The failure of immune surveillance may be associated with polyomavirus BK reactivation, potentially leading to the development of nephropathy in kidney transplantation. BK-specific cellular immune response may be used to modulate immunosuppressive therapy, but few studies have investigated the topic. Herein, we serially evaluated BK-specific response in 149 kidney transplant recipients and found that only 14/149 (9.4%) were responders. Episodes of viral reactivation (viremia and/or viruria) occurred only in non-responder patients. The frequency of BK-specific immune response appears to be lower than that for other persistently infecting viruses such as cytomegalovirus.
37
2
219
223
BKV; immune response; transplantation
Costa C.; Mantovani S.; Piceghello A.; Di Nauta A.; Sinesi F.; Sidoti F.; Messina M.; Cavallo R.
File in questo prodotto:
Non ci sono file associati a questo prodotto.

I documenti in IRIS sono protetti da copyright e tutti i diritti sono riservati, salvo diversa indicazione.

Utilizza questo identificativo per citare o creare un link a questo documento: http://hdl.handle.net/2318/154352
Citazioni
  • ???jsp.display-item.citation.pmc??? 4
  • Scopus 15
  • ???jsp.display-item.citation.isi??? 15
social impact