The risk of opportunistic infections caused by non-Candida yeasts and yeast-like fungi is increasingly common, mainly in immunocompromised patients. Appropriate first-line therapy has not been defined and standardized, mainly due to the low number of cases reported. To improve empirical treatment guidelines, we describe the susceptibility profile to fluconazole and voriconazole of 176 non-Candida yeasts and yeast-like fungi collected from hospitals in Piedmont, North West Italy from January 2009 to December 2013. The results showed that most isolates are susceptible to voriconazole (94%), but less susceptible to fluconazole (78%), suggesting that voriconazole could be used as first-line therapy in infections caused by these fungi.

In vitro antifungal activity of fluconazole and voriconazole against non-Candida yeasts and yeast-like fungi clinical isolates

MANDRAS, Narcisa
First
;
ROANA, Janira;SCALAS, Daniela;ALLIZOND, VALERIA;BANCHE, Giuliana;CUFFINI, Annamaria;TULLIO, Viviana Cristina
Last
2015

Abstract

The risk of opportunistic infections caused by non-Candida yeasts and yeast-like fungi is increasingly common, mainly in immunocompromised patients. Appropriate first-line therapy has not been defined and standardized, mainly due to the low number of cases reported. To improve empirical treatment guidelines, we describe the susceptibility profile to fluconazole and voriconazole of 176 non-Candida yeasts and yeast-like fungi collected from hospitals in Piedmont, North West Italy from January 2009 to December 2013. The results showed that most isolates are susceptible to voriconazole (94%), but less susceptible to fluconazole (78%), suggesting that voriconazole could be used as first-line therapy in infections caused by these fungi.
38
4
583
587
http://www.newmicrobiologica.org/PUB/allegati_pdf/2015/4/583.pdf
Yeasts, Yeast-like fungi, Fluconazole, Voriconazole, Susceptibility testing
Mandras, N; Roana, J; Scalas, D; Fucale, G; Allizond, V; Banche, G; Barbui, A; Li Vigni, N; Newell, V A.; Cuffini, AM; Tullio, V
File in questo prodotto:
File Dimensione Formato  
NewMicrobiologica_Mandras et al_2015.pdf

Accesso riservato

Tipo di file: PDF EDITORIALE
Dimensione 81.35 kB
Formato Adobe PDF
81.35 kB Adobe PDF   Visualizza/Apri   Richiedi una copia

I documenti in IRIS sono protetti da copyright e tutti i diritti sono riservati, salvo diversa indicazione.

Utilizza questo identificativo per citare o creare un link a questo documento: http://hdl.handle.net/2318/1559796
Citazioni
  • ???jsp.display-item.citation.pmc??? 3
  • Scopus 3
  • ???jsp.display-item.citation.isi??? 3
social impact