Cyclodextrin Derivatives as Stationary Phases for the GC Separation of Enantiomers in the Flavor and Fragrance Field

This chapter will examine the chiral recognition of volatile odorants in the flavour and fragrance field, by enantioselective gas chromatography (Es-GC) with cyclodextrin derivatives as chiral stationary phases. The first part looks at enantiomers and odour, the need for chiral recognition, and the evolution of chiral stationary phases for Es-GC. This is followed by a more detailed discussion of cyclodextrins and the theoretical aspects of enantiomer separation, and applications of these techniques to Es-GC. The next part deals with the strategy of routine chiral recognition using cyclodextrin derivatives as chiral stationary phases; this is also illustrated through some examples concerning real-world complex samples. This part briefly describes i) the potential of multidimensional techniques in routine analysis, ii) enantiomer automatic identification and recognition, iii) the role played by mass spectrometry in Es-GC-MS, iv) fast Es-GC in chiral recognition, and v) the use of total analysis systems in chiral recognition.