Clinical and biological prognostic factors in 135 patients affected by sinonasal carcinoma treated in Piedmont. Long-term survival of patients with sinonasal carcinoma remains disappointing in spite of aggressive treatment. The aim of the study is the assessment of overall survival in a group of patients treated with a fixed protocol and the positivity of proliferation and neoangiogenesis markers (Ki-67 and VEGF). From our data it comes out that staging, histological type and treatment are the most important clinical and pathological prognostic factors, moreover surgery +/- radiotherapy is the first line treatment for these tumors. Proliferation index and neoangiogenesis plays a pivotal role in the natural history of such neoplasms.

[Clinical and biological prognostic factors in 135 patients affected by sinonasal carcinoma treated in Piedmont]

RAIMONDO, Luca;GARZARO, Massimiliano;NAQE, Nertila;ZANARDI, Fabio Alessio;LAURIA, Alessandra;PECORARI, Giancarlo;GIORDANO, Carlo
2011-01-01

Abstract

Clinical and biological prognostic factors in 135 patients affected by sinonasal carcinoma treated in Piedmont. Long-term survival of patients with sinonasal carcinoma remains disappointing in spite of aggressive treatment. The aim of the study is the assessment of overall survival in a group of patients treated with a fixed protocol and the positivity of proliferation and neoangiogenesis markers (Ki-67 and VEGF). From our data it comes out that staging, histological type and treatment are the most important clinical and pathological prognostic factors, moreover surgery +/- radiotherapy is the first line treatment for these tumors. Proliferation index and neoangiogenesis plays a pivotal role in the natural history of such neoplasms.
33
3 Suppl
108
111
Adult; Aged; Aged, 80 and over; Carcinoma, Squamous Cell; Female; Head and Neck Neoplasms; Humans; Italy; Male; Middle Aged; Paranasal Sinus Neoplasms; Prognosis; Survival Rate; Young Adult
Raimondo, L; Garzaro, M; Naqe, N; Zanardi, F; Lauria, A; Pecorari, G; Giordano, C
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Utilizza questo identificativo per citare o creare un link a questo documento: https://hdl.handle.net/2318/1607732
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