Alpha-1 antitrypsin deficiency (AATD) is a clinically under-recognized inherited disorder affecting the lungs and the liver. The most common manifestations are pulmonary emphysema, bronchiectasis and liver disease. The recent publication of the European Respiratory Society statement on diagnosis and treatment of pulmonary diseases has replaced the 2003 American Thoracic Society and European Respiratory Society one. New outcome parameters have been introduced and validated by observational and randomized clinical trials, and new information about efficacy and safety of augmentation therapy have been published. In this narrative review we have commented the crucial points of the new European Respiratory Society statement on AATD, including a review of the literature on liver involvement and treatments.

Alpha1-antitrypsin deficiency: What's new after European Respiratory Society Statement

Patrucco F.;Venezia L.;Pellicano R.;Solidoro P.
2018

Abstract

Alpha-1 antitrypsin deficiency (AATD) is a clinically under-recognized inherited disorder affecting the lungs and the liver. The most common manifestations are pulmonary emphysema, bronchiectasis and liver disease. The recent publication of the European Respiratory Society statement on diagnosis and treatment of pulmonary diseases has replaced the 2003 American Thoracic Society and European Respiratory Society one. New outcome parameters have been introduced and validated by observational and randomized clinical trials, and new information about efficacy and safety of augmentation therapy have been published. In this narrative review we have commented the crucial points of the new European Respiratory Society statement on AATD, including a review of the literature on liver involvement and treatments.
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Alpha 1-antitrypsin deficiency; Emphysema; Liver diseases; Administration, Inhalation; Aerosols; Clinical Trials as Topic; Humans; Liver Diseases; Lung; Lung Diseases; Lung Transplantation; Pulmonary Disease, Chronic Obstructive; Pulmonary Emphysema; Pulmonary Medicine; Societies, Medical; alpha 1-Antitrypsin; alpha 1-Antitrypsin Deficiency
Patrucco F.; Venezia L.; Gavelli F.; Pellicano R.; Solidoro P.
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Utilizza questo identificativo per citare o creare un link a questo documento: http://hdl.handle.net/2318/1801424
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