In this study we report that addition to mixed lymphocyte reactions of monoclonal antibodies to interferon-gamma inhibits alloantigen recognition and induction of cytotoxic T lymphocytes by inducing early and highly effective suppressor T lymphocytes. This inhibitory activity is not confined to in vitro models, since daily local injection of these antibodies in CBA/J mice blocks the rejection of fully allogeneic tumor cells consistently displayed by untreated CBA/J mice.

Interferon-gamma plays a crucial role in T lymphocyte reaction against alloantigens. / LANDOLFO S ;COFANO F ;GIOVARELLI M ;PRAT M ;CAVALLO G ;FORNI G. - In: LA RICERCA IN CLINICA E IN LABORATORIO. - ISSN 0390-5748. - 15(1985), pp. 307-314.

Interferon-gamma plays a crucial role in T lymphocyte reaction against alloantigens.

LANDOLFO, Santo Giuseppe;GIOVARELLI, Mirella;
1985

Abstract

In this study we report that addition to mixed lymphocyte reactions of monoclonal antibodies to interferon-gamma inhibits alloantigen recognition and induction of cytotoxic T lymphocytes by inducing early and highly effective suppressor T lymphocytes. This inhibitory activity is not confined to in vitro models, since daily local injection of these antibodies in CBA/J mice blocks the rejection of fully allogeneic tumor cells consistently displayed by untreated CBA/J mice.
15
307
314
http://www.ncbi.nlm.nih.gov/pubmed/2939532
MoAb anti-IFN-gamma; alloreactivity inhibition
LANDOLFO S ;COFANO F ;GIOVARELLI M ;PRAT M ;CAVALLO G ;FORNI G
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Utilizza questo identificativo per citare o creare un link a questo documento: http://hdl.handle.net/2318/29792
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