The addition to mixed-leukocyte reactions of monoclonal antibodies to interferon-gamma abrogated alloantigen recognition and induction of cytotoxic T lymphocytes by inducing early and highly effective suppressor T lymphocytes. This inhibitory activity was not confined to in vitro models, since daily injection of the antibodies into CBA/J mice blocked the usual rejection of allogenic tumor cells.

Inhibition of interferon-gamma may suppress allograft reactivity by T lymphocytes in vitro and in vivo.

LANDOLFO, Santo Giuseppe;GIOVARELLI, Mirella;
1985

Abstract

The addition to mixed-leukocyte reactions of monoclonal antibodies to interferon-gamma abrogated alloantigen recognition and induction of cytotoxic T lymphocytes by inducing early and highly effective suppressor T lymphocytes. This inhibitory activity was not confined to in vitro models, since daily injection of the antibodies into CBA/J mice blocked the usual rejection of allogenic tumor cells.
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http://www.ncbi.nlm.nih.gov/pubmed/3160110
allograft reactivity; IFN-gamma; tumor graft inhibition
LANDOLFO S ;COFANO F ;GIOVARELLI M ;PRAT M ;CAVALLO G ;FORNI G
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Utilizza questo identificativo per citare o creare un link a questo documento: http://hdl.handle.net/2318/29793
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