HCMV infection is a major cause of morbidity and mortality following kidney transplantation. Clinical diagnosis is difficult, and rapid and sensitive diagnostic methods are needed since antiviral therapy is available. One hundred-forty-five consecutive kidney-transplanted patients were studied during a period of three months after transplantation. For laboratory diagnosis of HCMV infection, we looked for the presence of pp-65 antigen in polymorphonuclear leukocytes, HCMV-DNA and IgM. Demonstration of HCMV pp-65 antigen by immunofluorescence and HCMV DNA by PCR in leukocytes were efficient methods for early diagnosis of infection.

[Early diagnosis of HCMV infections in patients undergoing transplantation of the kidney] / CAVALLO R ;SINESI F ;RE D ;PIOVESAN F ;FORA R ;LEMBO D ;SEGOLONI GP ;TURELLO E ;NEGRO PONZI A. - In: GIORNALE DI BATTERIOLOGIA, VIROLOGIA ED IMMUNOLOGIA. - ISSN 0390-5462. - 86(1994), pp. 29-42.

[Early diagnosis of HCMV infections in patients undergoing transplantation of the kidney]

CAVALLO, Rossana;SINESI, Franca;LEMBO, David;SEGOLONI, Giuseppe;NEGRO PONZI, Alessandro
1994

Abstract

HCMV infection is a major cause of morbidity and mortality following kidney transplantation. Clinical diagnosis is difficult, and rapid and sensitive diagnostic methods are needed since antiviral therapy is available. One hundred-forty-five consecutive kidney-transplanted patients were studied during a period of three months after transplantation. For laboratory diagnosis of HCMV infection, we looked for the presence of pp-65 antigen in polymorphonuclear leukocytes, HCMV-DNA and IgM. Demonstration of HCMV pp-65 antigen by immunofluorescence and HCMV DNA by PCR in leukocytes were efficient methods for early diagnosis of infection.
86
29
42
CAVALLO R ;SINESI F ;RE D ;PIOVESAN F ;FORA R ;LEMBO D ;SEGOLONI GP ;TURELLO E ;NEGRO PONZI A
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Utilizza questo identificativo per citare o creare un link a questo documento: http://hdl.handle.net/2318/29856
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