A group of 45 children affected with Coeliac Disease (CD) was typed for HLA-A, B, C, D, and DR specificities. The most significant associations were found with two alleles of the D series, with both cellular and serological typing. It is suggested that the susceptibility to CD is determined by two different genes within the HLA region, the first in common with organ-specific autoimmune diseases and associated with DW3, the second possibly specific for CD and associated with Dw7.

Two HLA-D and DR alleles are associated with coeliac disease.

DE MARCHI, Mario;BORELLI, Iolanda;BARBERA, Cristiana;SANTINI, Bruna
1979-01-01

Abstract

A group of 45 children affected with Coeliac Disease (CD) was typed for HLA-A, B, C, D, and DR specificities. The most significant associations were found with two alleles of the D series, with both cellular and serological typing. It is suggested that the susceptibility to CD is determined by two different genes within the HLA region, the first in common with organ-specific autoimmune diseases and associated with DW3, the second possibly specific for CD and associated with Dw7.
14(4)
309
316
DeMarchi M; Borelli I; Olivetti E; Richiardi P; Wright P; Ansaldi N; Barbera C; Santini B.
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Utilizza questo identificativo per citare o creare un link a questo documento: https://hdl.handle.net/2318/31215
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