IgG and IgA antigluten antibodies (Gab) were assayed in 83 celiac disease (CD) patients typed for HLA and Gm markers. Their titer and frequency were lower when a gluten-free diet was given than in active CD; these were significantly correlated, whereas no correlation was found between titer and serum Ig. Persistence of high titers was mainly confined to HLA-DR3 negative females (45% vs 6.7% of DR3 positive females and 19.3% of males). No association was found with any Gm allotype, in contrast with the previously reported involvement of the 'fnb' haplotype with both CD susceptibility and Gab persistence in patients on a gluten-free diet. A technical and/or genetic explanation could be given for these differences.

HLA and antigluten antibodies in children with celiac disease.

BARBERA, Cristiana;DE MARCHI, Mario;
1987-01-01

Abstract

IgG and IgA antigluten antibodies (Gab) were assayed in 83 celiac disease (CD) patients typed for HLA and Gm markers. Their titer and frequency were lower when a gluten-free diet was given than in active CD; these were significantly correlated, whereas no correlation was found between titer and serum Ig. Persistence of high titers was mainly confined to HLA-DR3 negative females (45% vs 6.7% of DR3 positive females and 19.3% of males). No association was found with any Gm allotype, in contrast with the previously reported involvement of the 'fnb' haplotype with both CD susceptibility and Gab persistence in patients on a gluten-free diet. A technical and/or genetic explanation could be given for these differences.
5
158
161
Barbera C; Fusco P; Ansaldi N; DeMarchi M; Carbonara A.
File in questo prodotto:
Non ci sono file associati a questo prodotto.

I documenti in IRIS sono protetti da copyright e tutti i diritti sono riservati, salvo diversa indicazione.

Utilizza questo identificativo per citare o creare un link a questo documento: https://hdl.handle.net/2318/31303
Citazioni
  • ???jsp.display-item.citation.pmc??? 0
  • Scopus ND
  • ???jsp.display-item.citation.isi??? ND
social impact