Imipenem is a beta-lactam carbapenem antibiotic, N-formimidoyl thienamycin-derivate. Imipenem is highly active against gram-negative aerobes and also highly active against gram-positive aerobes and virtually all anaerobes, with MICs very low and MBCs equal or only two-four dilution higher, it has a low degree of affinity for all types of beta-lactamases, shown a good post-antibiotic effect, it is a potent inhibitor to peptidoglycan with a greatest affinity for PBP2 and PBP1, in gram-negative bacteria, and for PBP3, PBP1 and PBP4, in gram-positive bacteria. The precocious bactericidal activity belongs to its low molecular weight, the characteristic of zwitterionic compound, to its hydrophobicity and to, in finally, its compact molecular structure.

[In vitro activity of imipenem (N-formimidoylthienamycin), a new carbapenem antibiotic] / CAVALLO R ;CARLONE NA. - In: GIORNALE DI BATTERIOLOGIA, VIROLOGIA ED IMMUNOLOGIA. - ISSN 0390-5462. - 79(1986), pp. 228-243.

[In vitro activity of imipenem (N-formimidoylthienamycin), a new carbapenem antibiotic]

CAVALLO, Rossana;
1986

Abstract

Imipenem is a beta-lactam carbapenem antibiotic, N-formimidoyl thienamycin-derivate. Imipenem is highly active against gram-negative aerobes and also highly active against gram-positive aerobes and virtually all anaerobes, with MICs very low and MBCs equal or only two-four dilution higher, it has a low degree of affinity for all types of beta-lactamases, shown a good post-antibiotic effect, it is a potent inhibitor to peptidoglycan with a greatest affinity for PBP2 and PBP1, in gram-negative bacteria, and for PBP3, PBP1 and PBP4, in gram-positive bacteria. The precocious bactericidal activity belongs to its low molecular weight, the characteristic of zwitterionic compound, to its hydrophobicity and to, in finally, its compact molecular structure.
79
228
243
CAVALLO R ;CARLONE NA
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Utilizza questo identificativo per citare o creare un link a questo documento: http://hdl.handle.net/2318/31352
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