The genetic control of spontaneous resistance in vivo to increasing doses of a poorly immunogenic spontaneous adenocarcinoma (ADK-1t) of BALB/c origin was studied in F1 hybrid mice. The spontaneous resistance of homozygous parental BALB/c mice was not increased in F1 hybrids of BALB/c and BALB.B or BALB.K mice, even with small tumor challenges (10(3) cells). By contrast, it was significantly enhanced in F1 hybrids of BALB/c and several strains on A or B10 background. Resistance due to the acquisition of a new set of background genes was, however, markedly enhanced or suppressed by the presence of particular alleles located within or closely linked to the H-2 complex, as demonstrated by increasing the tumor challenge to 10(4) or 10 (5) cells. Spontaneous resistance, effective even with high tumor inocula, thus depended on a complex interplay between background and H-2 genes.

Interaction of H-2 and non-H-2 genes in spontaneous resistance to adenocarcinoma ADK-1t in F1 mice.

GIOVARELLI, Mirella;RENDINE, Sabina;LANDOLFO, Santo Giuseppe
1980

Abstract

The genetic control of spontaneous resistance in vivo to increasing doses of a poorly immunogenic spontaneous adenocarcinoma (ADK-1t) of BALB/c origin was studied in F1 hybrid mice. The spontaneous resistance of homozygous parental BALB/c mice was not increased in F1 hybrids of BALB/c and BALB.B or BALB.K mice, even with small tumor challenges (10(3) cells). By contrast, it was significantly enhanced in F1 hybrids of BALB/c and several strains on A or B10 background. Resistance due to the acquisition of a new set of background genes was, however, markedly enhanced or suppressed by the presence of particular alleles located within or closely linked to the H-2 complex, as demonstrated by increasing the tumor challenge to 10(4) or 10 (5) cells. Spontaneous resistance, effective even with high tumor inocula, thus depended on a complex interplay between background and H-2 genes.
65
651
655
http://www.ncbi.nlm.nih.gov/pubmed/6931938
genetic control; anti tumor immune reactivity
FORNI G ;SERRATI G ;GIORDANO L ;GIOVARELLI M ;RENDINE S ;LANDOLFO S
File in questo prodotto:
Non ci sono file associati a questo prodotto.

I documenti in IRIS sono protetti da copyright e tutti i diritti sono riservati, salvo diversa indicazione.

Utilizza questo identificativo per citare o creare un link a questo documento: http://hdl.handle.net/2318/32337
Citazioni
  • ???jsp.display-item.citation.pmc??? 0
  • Scopus ND
  • ???jsp.display-item.citation.isi??? ND
social impact