Pathological findings in various organs and tissues, T and B lymphocyte inability to proliferate towards several mitogens, and the appearance of serum interferon at progressive stages after intraperitoneal infection of BALB/c mice with Trypanosoma brucei brucei are reported. Heavy parasitaemia is evident throughout infection and complete hyporesponsiveness is already present on day 3. A sharp interferon production peak appears after 48 hours. The anatomopathological picture makes it clear that infection is substantially restricted to the blood. Secondary involvement of liver, lung and kidney takes the form of perivascular cuffs. These appear at relatively early stages. By contrast, spleen and lymph nodes appear to be greatly altered.

Immune depression in Trypanosoma brucei brucei infected mice. Sequential histological and immunological findings. / MARTINOTTI MG ;FORNI M ;DEL MONTE AM ;GIOVARELLI M ;FORNI G ;LANDOLFO S. - In: BOLLETTINO DELL'ISTITUTO SIEROTERAPICO MILANESE. - ISSN 0021-2547. - 60(1981), pp. 288-296.

Immune depression in Trypanosoma brucei brucei infected mice. Sequential histological and immunological findings.

GIOVARELLI, Mirella;LANDOLFO, Santo Giuseppe
1981

Abstract

Pathological findings in various organs and tissues, T and B lymphocyte inability to proliferate towards several mitogens, and the appearance of serum interferon at progressive stages after intraperitoneal infection of BALB/c mice with Trypanosoma brucei brucei are reported. Heavy parasitaemia is evident throughout infection and complete hyporesponsiveness is already present on day 3. A sharp interferon production peak appears after 48 hours. The anatomopathological picture makes it clear that infection is substantially restricted to the blood. Secondary involvement of liver, lung and kidney takes the form of perivascular cuffs. These appear at relatively early stages. By contrast, spleen and lymph nodes appear to be greatly altered.
60
288
296
http://www.ncbi.nlm.nih.gov/pubmed/6173044
Trypanosoma brucei brucei; immunodepression; interferon
MARTINOTTI MG ;FORNI M ;DEL MONTE AM ;GIOVARELLI M ;FORNI G ;LANDOLFO S
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Utilizza questo identificativo per citare o creare un link a questo documento: http://hdl.handle.net/2318/32346
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