The alloantigen differences stimulation migration inhibition factor (MIF) and immune interferon (i-IF) release in primary one-way murine mixed lymphocyte cultures are reported. Differences at H-2 and Mls coded alloantigens induce both MIF and i-IF release, while the differences at multiple minor histocompatibility antigens induce MIF release only. Both MIF and i-IF release are T-lymphocytes dependent events. However, while T-lymphocytes are sufficient for MIF release, the presence of macrophages is required for i-IF release.

Lymphokine production in primary mixed lymphocyte culture (MLC). III. Alloantigen signals cell-cell interactions involved in migration inhibition factor and immune interferon release. / LANDOLFO S ;GIOVARELLI M ;CAPUSSO A ;FORNI G. - In: BOLLETTINO DELL'ISTITUTO SIEROTERAPICO MILANESE. - ISSN 0021-2547. - 58(1979), pp. 128-132.

Lymphokine production in primary mixed lymphocyte culture (MLC). III. Alloantigen signals cell-cell interactions involved in migration inhibition factor and immune interferon release.

LANDOLFO, Santo Giuseppe;GIOVARELLI, Mirella;
1979

Abstract

The alloantigen differences stimulation migration inhibition factor (MIF) and immune interferon (i-IF) release in primary one-way murine mixed lymphocyte cultures are reported. Differences at H-2 and Mls coded alloantigens induce both MIF and i-IF release, while the differences at multiple minor histocompatibility antigens induce MIF release only. Both MIF and i-IF release are T-lymphocytes dependent events. However, while T-lymphocytes are sufficient for MIF release, the presence of macrophages is required for i-IF release.
58
128
132
LANDOLFO S ;GIOVARELLI M ;CAPUSSO A ;FORNI G
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Utilizza questo identificativo per citare o creare un link a questo documento: http://hdl.handle.net/2318/32352
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