The human leukemic T-cell line Hut 78, derived from a patient suffering from SÚzary syndrome and expressing a mature postthymic membrane phenotype, shows a c-myc rearrangement beginning within 500 base pairs immediately 3' to the c-myc exon 3. Chromosome analysis of the Hut 78 reveals the presence of a hyperdiploid karyotype with a large number of markers and rearrangements, though trisomy is the only cytogenetic anomaly involving chromosome 8. Moreover, as the abnormal c-myc appears to be duplicated, a duplication of the chromosome 8 carrying the abnormal c-myc probably occurred. Unlike four other human leukemic T-cell lines tested, the Hut 78 cells express a high amount of c-myc transcript, suggesting that the 3' c-myc anomaly may cause a deregulation of the expression of this gene.

3' c-myc rearrangement in a human leukemic T-cell line.

SAGLIO, Giuseppe;GUERRASIO, Angelo;SERRA, Anna;MALAVASI, Fabio;
1986-01-01

Abstract

The human leukemic T-cell line Hut 78, derived from a patient suffering from SÚzary syndrome and expressing a mature postthymic membrane phenotype, shows a c-myc rearrangement beginning within 500 base pairs immediately 3' to the c-myc exon 3. Chromosome analysis of the Hut 78 reveals the presence of a hyperdiploid karyotype with a large number of markers and rearrangements, though trisomy is the only cytogenetic anomaly involving chromosome 8. Moreover, as the abnormal c-myc appears to be duplicated, a duplication of the chromosome 8 carrying the abnormal c-myc probably occurred. Unlike four other human leukemic T-cell lines tested, the Hut 78 cells express a high amount of c-myc transcript, suggesting that the 3' c-myc anomaly may cause a deregulation of the expression of this gene.
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SAGLIO G; EMANUEL BS; A. GUERRASIO; GIUBELLINO MC; SERRA A; LUSSO P; CAMBRIN GR; MAZZA U; MALAVASI F; PEGORARO L
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Utilizza questo identificativo per citare o creare un link a questo documento: https://hdl.handle.net/2318/39752
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