The influence of caspofungin on polymorphonuclear leukocyte (PMN) phagocytosis and intracellular killing of Candida albicans was investigated. Caspofungin, at all of the concentrations tested (2, 3.2, and 8 mcg/ml), significantly increased intracellular killing by PMNs through its direct action on both yeast cells and PMNs, indicating the potential ability of caspofungin to synergize with phagocytes for candidal killing. Caspofungin may therefore constitute an effective therapeutic option for the treatment of invasive fungal infections, including those refractory to conventional treatment with azole agents.

Synergy of caspofungin with human polymorphonuclear granulocytes for killing Candida albicans

TULLIO, Viviana Cristina;MANDRAS, Narcisa;SCALAS, Daniela;ALLIZOND, VALERIA;BANCHE, Giuliana;ROANA, Janira;CUFFINI, Annamaria;CARLONE, Nicola
2010

Abstract

The influence of caspofungin on polymorphonuclear leukocyte (PMN) phagocytosis and intracellular killing of Candida albicans was investigated. Caspofungin, at all of the concentrations tested (2, 3.2, and 8 mcg/ml), significantly increased intracellular killing by PMNs through its direct action on both yeast cells and PMNs, indicating the potential ability of caspofungin to synergize with phagocytes for candidal killing. Caspofungin may therefore constitute an effective therapeutic option for the treatment of invasive fungal infections, including those refractory to conventional treatment with azole agents.
54
9
3964
3966
caspofungin; PMNs; Candida albicans; intracellular killing
Tullio V; Mandras N; Scalas D; Allizond V; Banche G; Roana J; Greco D; Castagno F; Cuffini AM; Carlone NA
File in questo prodotto:
File Dimensione Formato  
Caspofungina_AAC_2010.pdf

Accesso aperto

Tipo di file: PDF EDITORIALE
Dimensione 45.89 kB
Formato Adobe PDF
45.89 kB Adobe PDF Visualizza/Apri
AAC 2010 Tullio.pdf

Accesso riservato

Tipo di file: PDF EDITORIALE
Dimensione 46.72 kB
Formato Adobe PDF
46.72 kB Adobe PDF   Visualizza/Apri   Richiedi una copia

I documenti in IRIS sono protetti da copyright e tutti i diritti sono riservati, salvo diversa indicazione.

Utilizza questo identificativo per citare o creare un link a questo documento: http://hdl.handle.net/2318/74740
Citazioni
  • ???jsp.display-item.citation.pmc??? 5
  • Scopus 12
  • ???jsp.display-item.citation.isi??? 12
social impact