α-enolase (ENOA) is a metabolic enzyme involved in the synthesis of pyruvate. It also acts as a plasminogen receptor and thus mediates activation of plasmin and extracellular matrix degradation. In tumor cells, ΕΝΟΑ is upregulated and supports anaerobic proliferation (Warburg effect), it is expressed at the cell surface, where it promotes cancer invasion, and is subjected to a specific array of post-translational modifications, namely acetylation, methylation and phosphorylation. Both ENOA overexpression and its post-translational modifications could be of diagnostic and prognostic value in cancer. This review will discuss recent information on the biochemical, proteomics and immunological characterization of ENOA, particularly its ability to trigger a specific humoral and cellular immune response. In our opinion, this information can pave the way for effective new therapeutic and diagnostic strategies to counteract the growth of the most aggressive human disease.

α-enolase: a promising therapeutic and diagnostic tumor target

CAPELLO, Michela;CAPPELLO, Paola;NOVELLI, Francesco
2011-01-01

Abstract

α-enolase (ENOA) is a metabolic enzyme involved in the synthesis of pyruvate. It also acts as a plasminogen receptor and thus mediates activation of plasmin and extracellular matrix degradation. In tumor cells, ΕΝΟΑ is upregulated and supports anaerobic proliferation (Warburg effect), it is expressed at the cell surface, where it promotes cancer invasion, and is subjected to a specific array of post-translational modifications, namely acetylation, methylation and phosphorylation. Both ENOA overexpression and its post-translational modifications could be of diagnostic and prognostic value in cancer. This review will discuss recent information on the biochemical, proteomics and immunological characterization of ENOA, particularly its ability to trigger a specific humoral and cellular immune response. In our opinion, this information can pave the way for effective new therapeutic and diagnostic strategies to counteract the growth of the most aggressive human disease.
278
1064
1074
http://onlinelibrary.wiley.com/doi/10.1111/j.1742-4658.2011.08025.x/abstract
α-enolase; cancer; immune response; post-translational modifications; tumor-associated antigen
Capello M; Ferri-Borgogno S; Cappello P; Novelli F.
File in questo prodotto:
File Dimensione Formato  
Capello M et al_FEBS 2011.pdf

Accesso riservato

Tipo di file: PDF EDITORIALE
Dimensione 6.63 MB
Formato Adobe PDF
6.63 MB Adobe PDF   Visualizza/Apri   Richiedi una copia
FEBS_J_281210 Michela.pdf

Accesso aperto

Tipo di file: PREPRINT (PRIMA BOZZA)
Dimensione 144.06 kB
Formato Adobe PDF
144.06 kB Adobe PDF Visualizza/Apri

I documenti in IRIS sono protetti da copyright e tutti i diritti sono riservati, salvo diversa indicazione.

Utilizza questo identificativo per citare o creare un link a questo documento: https://hdl.handle.net/2318/87800
Citazioni
  • ???jsp.display-item.citation.pmc??? 109
  • Scopus 192
  • ???jsp.display-item.citation.isi??? 187
social impact